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Secondary, non-primary-source reporting on the Pyo paper also describes an inverted, inhibitory response at higher concentrations, in the 10 to the minus 8 to 10 to the minus 7 molar range, suggesting a biphasic or hormetic dose curve

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In the 12 mg group, every participant lost at least 5 percent, 93 percent lost at least 10 percent, and 83 percent lost at least 15 percent